Remyelination After Cuprizone-Induced Demyelination Is Accelerated in Juvenile Mice
نویسندگان
چکیده
منابع مشابه
Remyelination After Cuprizone-Induced Demyelination Is Accelerated in Juvenile Mice.
Remyelination capacity decreases with age in adult mice, but data comparing remyelination capacity after toxic demyelination in developing mice versus adult mice are not available. We treated 3-week-old and adult C57BL/6 mice with cuprizone for 1 to 5 weeks and studied demyelination/remyelination and cellular reactions in the corpus callosum and motor cortex by histology, immunohistochemistry, ...
متن کاملProgesterone Enhanced Remyelination in the Mouse Corpus Callosum After Cuprizone Induced Demyelination
Background: Progesterone as a sex steroid hormone is thought to affect and prevent demyelination, but its role in promoting myelin repair is far less investigated. In this study, remyelinating potential of progesterone in corpus callosum was evaluated on an experimental model of MS.Methods: In this experimental study, adult male C57BL/6 mice were fed with 0.2% (w/w) cuprizone in ground breeder ...
متن کاملAn Alternative Cuprizone-Induced Demyelination and Remyelination Mouse Model
The cuprizone model is a well-established and investigated paradigm to study demyelination and remyelination in rodents. Cuprizone is usually administrated by mixing in the powdered or pelleted rodent chow. However, since cuprizone is sensitive to the environment and the consumption of it varies between different animals, the major issue is the discrepancy in demyelination of the animals. This ...
متن کاملProgesterone Enhanced Remyelination in the Mouse Corpus Callosum after Cuprizone Induced Demyelination
BACKGROUND Progesterone as a sex steroid hormone is thought to affect and prevent demyelination, but its role in promoting myelin repair is far less investigated. In this study, remyelinating potential of progesterone in corpus callosum was evaluated on an experimental model of MS. METHODS In this experimental study, adult male C57BL/6 mice were fed with 0.2% (w/w) cuprizone in ground breeder...
متن کاملprogesterone enhanced remyelination in the mouse corpus callosum after cuprizone induced demyelination
background: progesterone as a sex steroid hormone is thought to affect and prevent demyelination, but its role in promoting myelin repair is far less investigated. in this study, remyelinating potential of progesterone in corpus callosum was evaluated on an experimental model of ms. methods: in this experimental study, adult male c57bl/6 mice were fed with 0.2% (w/w) cuprizone in ground breeder...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2015
ISSN: 0022-3069,1554-6578
DOI: 10.1097/nen.0000000000000214